The Treatment of Autoimmune Hemolytic Anemia with 6-Mercaptopurine and Thiognanine
نویسنده
چکیده
By ROBERT SCHWARTZ AND WILLIAM DAMESHEK P RIOR TO 1949, the treatment of autoimmune hemolytic anemia ( AIHA) was frequently disappointing. Despite splenectomy and the use of blood transfusions, many patients had an unremitting and progressively deteriorating course which ended fatally. With the introduction of ACTH and cortisone, the treatment of this disorder was greatly facilitated and beneficial results became far more consistent.1 Today the corticosteroids, and especially the newer synthetic agents, such as prednisone, may be said to constitute the treatment of choice in AIHA, splenectomy being reserved for refractory cases. During the past three years we have become interested in another series of compounds, the antimetabolite purine analogues, as a mode of treatment for this condition. Following the demonstration that six-mercaptopiirine ( 6-MP) could suppress immune responses in experimental animals,2’ we explored the possible value of this material in human autoimmune disease, notably in AIHA and systemic lupus, and reported the results in a preliminary paper.4 It is the purpose of this paper to present our experiences in the treatment of 14 cases of autoimmune hemolytic anemia with 6-MP and a related analogue, thioguanme.
منابع مشابه
Treatment of autoimmune hemolytic anemia in children with azathioprine (imuran).
velopment of azathioprine ( Imuran ) , a derivative of 6-mercaptopurine. The efficacy of purine antagonists has been proved in clinical trials by suppression of homograft rejection and autoimmune diseases, particularly autoimmune hemolytic anemia/LlT Several publications deal with the application of this treatment to adults, ’4’1 #{176}’17 but to the best of our knowledge this is the first comm...
متن کاملThe Treatment of Autoimmune Hemolytic Anemia with 6 - Mercaptopurine
By ROBERT SCHWARTZ AND WILLIAM DAMESHEK P RIOR TO 1949, the treatment of autoimmune hemolytic anemia ( AIHA) was frequently disappointing. Despite splenectomy and the use of blood transfusions, many patients had an unremitting and progressively deteriorating course which ended fatally. With the introduction of ACTH and cortisone, the treatment of this disorder was greatly facilitated and benefi...
متن کاملThe treatment of autoimmune hemolytic anemia.
By ROBERT SCHWARTZ AND WILLIAM DAMESHEK P RIOR TO 1949, the treatment of autoimmune hemolytic anemia ( AIHA) was frequently disappointing. Despite splenectomy and the use of blood transfusions, many patients had an unremitting and progressively deteriorating course which ended fatally. With the introduction of ACTH and cortisone, the treatment of this disorder was greatly facilitated and benefi...
متن کاملThrombocytopenic purpura in patient with autoimmune haemolytic anaemia, successfully treated with mercaptopurine.
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Successful Treatment of Refractory Autoimmune Hemolytic Anemia (AIHA) in a Child, Based on Iranian Traditional Medicine: A Case Report
Autoimmune hemolytic anemia (AIHA) is a heterogeneous and relatively unknown disease caused by premature immune destruction of red blood cells. While its occurrence is uncommon among children, it is sometimes severe and resistant to treatment. The warm-reactive type contains 70% to 80% of all cases, in which the first-line treatment is considered to be a steroid. Moreover, splenectomy, rituxima...
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